The institute just announced the gift, though it was made by Dr. Springer, his wife and his children at the end of 2020.
Dr. Springer has a net worth of about $1.9 billion and launched the institute in 2017 with a $40 million donation.
IPI focuses on providing antibodies and protein-based tools to the scientific community.
Dr. Springer earned his wealth as a founding investor in Moderna, which he owned 5 percent of when it went public in 2018.